Data from a new study indicate that an immunoconjugate vaccine reduces the antinociceptive, behavioral and physiologic effects of fentanyl, in experimental rats.
The vaccine is composed of a fentanyl-like hapten that includes a linker with a carboxyl moiety suitable for carbodiimide coupling chemistry in order to create amide bonds with lysine residues on the carrier protein CRM197—a genetically deactivated diphtheria toxin contained in several FDA-approved conjugate vaccines, researchers