Figure. Modifications of tool compound GSK205 for improved targeting of TRPV4. The synthesized compounds differed in the highlighted part of the molecule, changed residue indicated with arrow. Compound 16-19 was synthesized to incorporate two modifications from two compounds, 16-8 and 16-18, found most potent in anti-TRPV4 screening assays.
TRPV4, transient receptor potential vanilloid 4
TRPV4, transient receptor potential vanilloid 4
Source: Wolfgang Liedtke, MD, PhD, Duke University.
A new study has described two novel compounds that