Data published in Brain indicate that blocking the activity of an enzyme, Tiam1 (T-cell lymphoma invasion and metastasis 1), in spinal neurons inhibits morphine tolerance and pain hypersensitivity.
“Our work uncovers a previously unknown mechanism that underlies opioid tolerance and provides a promising therapeutic target to reduce tolerance and prolong the usefulness of morphine in chronic pain management,” study author Lingyong Li, PhD, of the Department of Anesthesiology and