Selective Inhibition of NaV1.8 With VX-548 for Acute Pain

Jones J, Correll DJ, Lechner SM, et al. Selective inhibition of NaV1.8 with VX-548 for acute pain. N Engl J Med. 2023;389(5):393-405.

Commonly used pharmaceuticals for pain management include opioid receptor agonists (oxycodone), nonselective sodium channel antagonists (lidocaine), nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen.¹ Researchers have identified a voltage-gated