A recent study found some evidence that serotonin–norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TAs) and selective serotonin reuptake inhibitors (SSRIs) were effective at relieving pain in people with certain conditions.
The study analyzed 26 systematic reviews that included more than 156 unique trials and more than 25,000 patients (BMJ 2023;380:e072415). The efficacy of eight antidepressant classes for treating 22 different pain conditions was assessed. The