Talarozole (R115866, Janssen), known to increase retinoic acid, has demonstrated the ability to prevent osteoarthritis (OA) in disease models.
Currently, there are no effective disease-modifying treatments to relieve the symptoms of OA. More than 40% of people will develop it in their lifetime.
According to researchers, common polymorphic variants in the protein that encodes the key enzyme for synthesis of all-trans retinoic acid (ALDH1A2) are associated with severe hand OA (Sci Transl Med